[Role of TLR4/NF-κB pathway for early change of synovial membrane in knee osteoarthritis rats].

Abstract

NF-κB pathway could mediate occurrence of KOA by early activating and triggeringg synovial increasingly secreting inflammatory secretion CD14, TLR4, IL-1β, TNF-α, ADAMTS-4, MMP-13, PIIINP and HA.