Efecto histoprotector de Aloe vera L. "sábila" en ratas con daño gástrico provocado por indometacina
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Rev. Inv. Cs. Agro. y Vet.
Abstract
RESUMEN: Se evaluó el efecto histoprotector de Aloe vera L. "sábila" en ratas con daño gástrico provocado por indometacina. Sé utilizó 50 ratas, de 4 meses de edad y de 250 g de peso promedio. Los animales se distribuyeron en grupo de diez para cada uno de los tratamientos. El grupo 1 (testigo) recibió SSF (0, 9%), el grupo 2 (control) se administró indometacina (20 mg/kg), y los grupos problema (3, 4 y 5) recibieron una, dos y tres dosis de sábila (50 mg/kg), respectivamente. La primera dosis se administró a las 4 horas procedentes a la indometacina y las demás dosis con sucesiones de 4 horas. Transcurrida una hora fueron anestesiadas y sacrificadas. En los niveles de lesiones gástricas macroscópicas y microscópicas se hallaron significativamente diferencias entre el grupo control (p< 0.001) y los grupos problema. En los grupos tratados con A. vera L. (p>0.05) no se encontró diferencias significativas. En nuestras condiciones experimentales la aplicación de un extracto de sábila en ratas con daño gástrico presentó efecto histoprotector.
ABSTRACT: The cytoprotective effect of Aloe vera L. "aloe" was evaluated in rats with gastric damage caused by indomethacin. 50 rats, 4 months old and 250 g of average weight, were used. The animals were distributed in a group of ten for each of the treatments. Group 1 (control) received SSF (0.9%), group 2 (control) received indomethacin (20 mg / kg), and problem groups (3, 4, and 5) received one, two, and three doses of aloe (50 mg / kg), respectively. The first dose was administered 4 hours before indomethacin and the other doses in 4-hour successions. After one hour they were anesthetized and euthanized. In the levels of macroscopic and microscopic gastric lesions, significant differences were found between the control group (p <0.001) and the problem groups. In the groups treated with A. vera L. (p> 0.05), no significant differences were found. In our experimental conditions the application of an extract of aloe in rats with gastric damage showed histoprotective effect.
ABSTRACT: The cytoprotective effect of Aloe vera L. "aloe" was evaluated in rats with gastric damage caused by indomethacin. 50 rats, 4 months old and 250 g of average weight, were used. The animals were distributed in a group of ten for each of the treatments. Group 1 (control) received SSF (0.9%), group 2 (control) received indomethacin (20 mg / kg), and problem groups (3, 4, and 5) received one, two, and three doses of aloe (50 mg / kg), respectively. The first dose was administered 4 hours before indomethacin and the other doses in 4-hour successions. After one hour they were anesthetized and euthanized. In the levels of macroscopic and microscopic gastric lesions, significant differences were found between the control group (p <0.001) and the problem groups. In the groups treated with A. vera L. (p> 0.05), no significant differences were found. In our experimental conditions the application of an extract of aloe in rats with gastric damage showed histoprotective effect.
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Vol. 5, No. 14