Validación del efecto fitoterápico de un medicamento en base a extractos vegetales de lupinus/aloe (regumetacel) para el tratamiento de la diabetes tipo 11, artritis reumática, artrosis, y gastritis. Sucre 2006 - 2015
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Rev. Cien. Tec. In.
Abstract
El objetivo de la presente investigación, fue validar en dos fases, el efecto de un Medicamento Fitoterápico en base a extractos vegetales de Lupinus/Aloe, denominado (REGUMETACEL) para el tratamiento de la Diabetes Tipo 11, Artritis 3-otosa Reumática, Artrosis, Gastritis, mediante estudios de caso. En la Iº fase del sstudio se validó la dosificación tomando en cuenta el uso tradicional en las comunidades de Chaqui del Departamento de Potosí, ensayos de laboratorio y clínico. En la segunda fase se realizó un seguimiento control del 2006 al 2015. La dosis promedio validada fue de 2,7 mg/kg de peso corporal. La metodología utilizada fue de tipo explorativo-descriptivo y experimental mediante evaluación y observación continua de la unidad de investigación, representada por individuos 'cuatro casos de estudio), los cuales tenían entre un avance moderado (codificados como 1) y (grave como 2) de las enfermedades de (Diabetes, Gastritis - Artritis gotosa) (Gastritis-Artrosis). El tratamiento de inicio, en los pacientes codificados 1 fue valorado a los 30, 60, 90 y 120 días con intervalos de descanso de cinco días por cada 15 días de toma, en los pacientes codificados 2 se aplicó el tratamiento después de los 30 días de administrado a los codificados 1, para determinar el efecto producido en el primer mes. Los pacientes para el estudio fueron seleccionados de aquellos que no contaban a la fecha con medicación convencional o que lo habían dejado, se realizó el seguimiento control del tratamiento con REGUMETACEL mediante pruebas de laboratorio y vigilancia, (dosificación de 60 mg c/8 hrs.180 mg 'día de extracto puro de Lupinus m. estabilizado con Aloe vera) el resultado fue significativo F= (32,2); p=0.042, F=(2,7); p=0.025 comprobándose de esta manera la eficacia del efecto fitoterápico natural del extracto sólido de Lupinus /Aloe para las enfermedades indicadas, el tratamiento realizado fue acompañado de una dieta alimenticia flexible y sana (frutas, verduras, carne blanca, evitando el consumo de carnes rojas). La 2º Fase del estudio consistió en evaluar de forma continua el tratamiento efectuado con una dosis de mantenimiento durante dos años, en el año 1 pos tratamiento, se realizó el control con dosis única 60 mg /día, intervalos mes a mes de 10 días de descanso, a partir del 2º año dosis única 45 mg/día con intervalos de descanso mes a mes de 15 días, a partir del año 3 hasta el año 10, se realizó el seguimiento control laboratorial de parámetros de laboratorio utilizados como indicadores y mediante la observación, en donde se pudo apreciar los resultados relativamente constantes entre el 95 y 98 % en los pacientes sometidos a estudio, verificando a la vez que los mismos, utilizan el producto entre 5 y 15 días como desintoxicante post comidas opíparas y el desarrollo de una vida normal saludable sin efecto secundario alguno a las dosis utilizada, lo que nos permitió concluir que las propiedades curativas de los principios activos con los que cuenta REGUMETACEL (Extracto de Lupinus /Aloe: preparado, estabilizado y dosificado) y a las que debe su actividad fitoterápica, permiten que las células regulen el funcionamiento de su METABOLISMO devolviéndole la actividad funcional al organismo, por lo que el producto ha sido denominado REGUMETACEL ^REGULADOR DEL MATABOLISMO CELULAR, La dosis promedio especificada para un individuo de 74 kg de peso por día, es de 200 mg, una DL arriba de 3 mg/Kg.
The aim of this investigation was to valídate the effect of a Phytotherapic medicine based on plant extracts of Lupmus/Aloe called REGUMETACEL for the treatment of Diabetes type II, Rheumatic Gouty Arthritis, Osteoarthritis and Gastritis through different case studies. In the first phase of the study, the dosage was validated taking into account the traditional use in the Chaqui communities of the Department of Potosí-Bolivia, laboratory and clinical tests. In the second phase a control of the dosage was monitored from 2006 to 2015. The average validated dose was 2.7 mg/kg body weight. The methodology used for this study was an exploratory-descriptive and experimental type by the evaluation and continuous observation of the research unit, represented by individuáis (four case studies) which had between a modérate (coded as 1) and severe (coded as 2) progression of diseases such as diabetes, gastritis - gouty Arthritis, Gastritis-Osteoarthritis. The actual start of the treatment in patients coded as (1) was assessed at 30, 60, 90 and 120 days with rest intervals of five days for every 15 days of taking. In patients coded as (2), the treatment was applied after the 30 days of the dose administered to the patients coded as 1 in order to determine the effect produced in the first month. Patients for this study were selected from those who did not currently have conventional medication or who left it. The monitoring and control of the treatment with REGUMETACEL was performed through laboratory tests and surveillance (60 mg/8 hours dosing; 180 mg/day of puré extract of Lupinus stabilized with Aloe vera). The result was significant F= (32,2); p=0.042, F=(2,7); p=0.025 thus confirming the efficacy of the natural phytotherapeutic effect of Lupinus/Aloe solid extract for the indicated diseases. The treatment was accompanied by a healthy and flexible diet (fruits, vegetables, white meat, avoiding the consumption of red meat). The second phase of the study consisted in a continuously evaluation of the treatment performed with a maintenance dose for two years. In the first year of post treatment, control was performed with a single dose of 60 mg/day, month-to-month intervals of 10 days of rest. From the second year, a single dose of 45 mg/day with rest intervals month to month of 15 days. From year 3 to year 10, laboratory monitoring and control of laboratory parameters used as indicators and by observation were performed, where it was possible to appreciate the relatively constant results between 95 and 98% in the patients under study. At the same time verifying that they use the product between 5 and 15 days as a detoxifier after sumptuous banquets and the development of a normal healthy life without any side effect at the doses used. This results allowed to conclude that the curative properties of the active ingredients with REGUMETACEL (Lupinus / Aloe extract: prepared, stabilized and dosed) and which owes its phytotherapeutic activity, allows the cells to regúlate the functioning of their metabolism returning the functional activity to the organism, the reason why the product has been denominated REGUMETACEL (REGULATOR OF CELL METABOLISM). The average dose per day specified for an individual of 74 kg of weight, is of 200 mg and a DL above 3 mg / kg.
The aim of this investigation was to valídate the effect of a Phytotherapic medicine based on plant extracts of Lupmus/Aloe called REGUMETACEL for the treatment of Diabetes type II, Rheumatic Gouty Arthritis, Osteoarthritis and Gastritis through different case studies. In the first phase of the study, the dosage was validated taking into account the traditional use in the Chaqui communities of the Department of Potosí-Bolivia, laboratory and clinical tests. In the second phase a control of the dosage was monitored from 2006 to 2015. The average validated dose was 2.7 mg/kg body weight. The methodology used for this study was an exploratory-descriptive and experimental type by the evaluation and continuous observation of the research unit, represented by individuáis (four case studies) which had between a modérate (coded as 1) and severe (coded as 2) progression of diseases such as diabetes, gastritis - gouty Arthritis, Gastritis-Osteoarthritis. The actual start of the treatment in patients coded as (1) was assessed at 30, 60, 90 and 120 days with rest intervals of five days for every 15 days of taking. In patients coded as (2), the treatment was applied after the 30 days of the dose administered to the patients coded as 1 in order to determine the effect produced in the first month. Patients for this study were selected from those who did not currently have conventional medication or who left it. The monitoring and control of the treatment with REGUMETACEL was performed through laboratory tests and surveillance (60 mg/8 hours dosing; 180 mg/day of puré extract of Lupinus stabilized with Aloe vera). The result was significant F= (32,2); p=0.042, F=(2,7); p=0.025 thus confirming the efficacy of the natural phytotherapeutic effect of Lupinus/Aloe solid extract for the indicated diseases. The treatment was accompanied by a healthy and flexible diet (fruits, vegetables, white meat, avoiding the consumption of red meat). The second phase of the study consisted in a continuously evaluation of the treatment performed with a maintenance dose for two years. In the first year of post treatment, control was performed with a single dose of 60 mg/day, month-to-month intervals of 10 days of rest. From the second year, a single dose of 45 mg/day with rest intervals month to month of 15 days. From year 3 to year 10, laboratory monitoring and control of laboratory parameters used as indicators and by observation were performed, where it was possible to appreciate the relatively constant results between 95 and 98% in the patients under study. At the same time verifying that they use the product between 5 and 15 days as a detoxifier after sumptuous banquets and the development of a normal healthy life without any side effect at the doses used. This results allowed to conclude that the curative properties of the active ingredients with REGUMETACEL (Lupinus / Aloe extract: prepared, stabilized and dosed) and which owes its phytotherapeutic activity, allows the cells to regúlate the functioning of their metabolism returning the functional activity to the organism, the reason why the product has been denominated REGUMETACEL (REGULATOR OF CELL METABOLISM). The average dose per day specified for an individual of 74 kg of weight, is of 200 mg and a DL above 3 mg / kg.
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Vol. 15, No. 16