SECONDARY METABOLITES FROM CAESALPINIA PLUVIOSA
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Rev. Bol. Quim
Abstract
Dos compuestos fenólicos, galato de etilo y rhuschalcona VI, junto con lupeol, ácido betulínico y estigmasterol fueron aislados de la corteza de Caesalpinia pluviosa DC. Sus estructuras fueron determinadas por medios espectroscópicos, completando todos los asignamientos de RMN de los compuestos fenólicos. Además, los extractos y compuestos puros fueron evaluados contra la bacteria Staphylococcus aureus, la prueba HPIA y el ensayo antimalarico in vitro contra Plasmodium falciparum determinando que el extracto CH2Cl2 y rhuschalcone VI muestran buena actividad en las pruebas antibacterianas y HPIA.
Two phenolic compounds, ethyl gallate and rhuschalcone VI, together with lupeol, betulinic acid and stigmasterol were isolated from the stem bark of Caesalpinia pluviosa D.C. Their structures were determined by spectroscopic means mainly by NMR experiments, completing all the NMR assignments of phenolic compounds. In addition, the extracts and pure compounds were evaluated against the bacteria Staphylococcus aureus, HPIA test and the antimalarial in vitro assay against Plasmodium falciparum, determining that CH2Cl2 extract and rhuschalcone VI showed good activity in the antibacterial and HPIA tests.
Two phenolic compounds, ethyl gallate and rhuschalcone VI, together with lupeol, betulinic acid and stigmasterol were isolated from the stem bark of Caesalpinia pluviosa D.C. Their structures were determined by spectroscopic means mainly by NMR experiments, completing all the NMR assignments of phenolic compounds. In addition, the extracts and pure compounds were evaluated against the bacteria Staphylococcus aureus, HPIA test and the antimalarial in vitro assay against Plasmodium falciparum, determining that CH2Cl2 extract and rhuschalcone VI showed good activity in the antibacterial and HPIA tests.
Description
Vol. 23, No. 1