¿La senescencia celular promueve el envejecimiento biológico? Scoping review

Abstract

Cellular senescence is a response mechanism against damage elements, it consists in the arrest of cell divisions; Therefore, the cell remains viable and the damage suffered is not transmissible to subsequent generations, however, current evidence indicates that this kind of cells is more predominant in tissues of individuals with greater biological age and the presence of certain markers that express molecular damage, this aims to answer the following research question: does cellular senescence promote biological aging? A scoping review was carried out based on the extension guide of the PRISMA statement extension guide and with the Joanna Briggs Institute guidelines for systematic scoping review, using the PubMed, Scopus and Google Scholar databases. Articles published in the last 5 years were selected. the inclusion criteria include all types of possible studies published in English with dates between November 30, 2019 and January 1, 2021, the search yielded 579 articles of which 53 were selected after their respective review. These selected articles show that (41) were identified as documentary studies of which (39) were review articles and (2) used databases from previous studies; (11) were experimental studies of which (5) were in vivo and (6) in vitro studies. Due to the multiple cellular and biochemical factors involved, more data is required to infer a direct causal association of aging on tissues.