Depuración de lactato a gran altitud
Date
Journal Title
Journal ISSN
Volume Title
Publisher
Cuad. - Hosp. Clín.
Abstract
Objetivo: El estudio pretende caracterizar la depuración de Iactato (DL) en pacientes críticamente enfermos, a gran altitud. Diseño: Estudio prospectivo de cohorte. Ámbito: Unidad de Cuidados Intensivos de Adultos del Hospital del Norte de la ciudad de El Alto, La Paz (Bolivia), a 4 150 metros sobre el nivel del mar, periodo 25 de abril 2016-01 de junio 2018. Pacientes: Todos los pacientes ingresados a la Unidad de Cuidados Intensivos de Adultos, nativos de gran altitud, así como residentes de la misma por lo menos los últimos 6 meses. Resultados: Se incluyeron 250 pacientes, con sobrevida de 68%, promedio de edad 50 años; en el grupo de 170 supervivientes, poco más de la cuarta parte del Iactato de ingreso fue depurado (26%), a comparación del grupo de 80 fallecidos, en el cual incluso el valor de Iactato se vio incrementado alrededor de la quinta parte del Iactato de ingreso (21 %), ambos con p ≤ 0.05 mediante el test de ANOVA. En pacientes críticamente enfermos a gran altitud, el riesgo relativo entre depuración de Iactato ≥ 26% y sobrevida es de 2.7 con sensibilidad 0.72 y especificidad de 1. Discusión y Conclusiones: La depuración de Iactato en individuos críticamente enfermos nativos de gran altitud, se asocia a mayor sobrevida y debería ser considerado como un objetivo durante la reanimación en pacientes críticos, de forma similar a estudios realizados en otras latitudes.
Objective: To characterize the lactate clearance on criticaiiy ill patients, at high aititude. Desing: Prospective cohort study. Field: Critical Care Unit of "Hospital del Norte" in El Alto, La Paz (Bolivia), during the period April 25, 2016-June 01, 2018. Participants: Críticaiiy ill patients residents of high aititude at Ieast the Iast 6 months, admitted to the Adult Critical Care Unit. Results: 250 patients were included, with survival of 68%, age average of 50 years; in the 170 survivors, lactate clearance average was 26%, in contrast with 80 deceased patients who presented an increased lactate level of 25%, p ≤ 0.05, both of them through ANOVA test. In high landers críticaiiy ill patients, relative risk of lactate clearance > 26% and survival was 2.7 with sensitivity 0.72 and specificity 1. Discussion and Conclusions: Lactate clearance in críticaiiy ill high landers dwellers, is associated with survival and it should be considered also as a reanimation objective, comparable to other studies developed in different latitudes.
Objective: To characterize the lactate clearance on criticaiiy ill patients, at high aititude. Desing: Prospective cohort study. Field: Critical Care Unit of "Hospital del Norte" in El Alto, La Paz (Bolivia), during the period April 25, 2016-June 01, 2018. Participants: Críticaiiy ill patients residents of high aititude at Ieast the Iast 6 months, admitted to the Adult Critical Care Unit. Results: 250 patients were included, with survival of 68%, age average of 50 years; in the 170 survivors, lactate clearance average was 26%, in contrast with 80 deceased patients who presented an increased lactate level of 25%, p ≤ 0.05, both of them through ANOVA test. In high landers críticaiiy ill patients, relative risk of lactate clearance > 26% and survival was 2.7 with sensitivity 0.72 and specificity 1. Discussion and Conclusions: Lactate clearance in críticaiiy ill high landers dwellers, is associated with survival and it should be considered also as a reanimation objective, comparable to other studies developed in different latitudes.
Description
Vol. 60, No. 1