Los polimorfismos del gen IL28B no se asocian con el riesgo de infección por HTLV-1: un metaanálisis
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Gac Med Bol
Abstract
La búsqueda de factores genéticos de riesgo es importante para comprender la susceptibilidad al Virus Linfotrópico TTipo 1 Humano (HTLV-1), aunque los polimorfismos del gen IL28B se han asociado con el riesgo de infección en otros virus, su papel en el riesgo de infección por HTLV-1 permanece incierto. Objetivo: determinar si los Polimorfismos de un Solo Nucleótido (SNP) rs8099917 y rs12979860 del gen IL28B están asociados con el riesgo de infección HTLV-1. Material y métodos: se realizó un metaanálisis de estudios de casos y controles, se efectúo una búsqueda en Pubmed, Google Scholar y Scopus. Se extrajeron frecuencias genotípicas de los polimorfismos. Mediante un metaanálisis de asociación genética empleando el programa Metagenyo, se estimaron Odds Ratios (OR) e intervalos de confianza al 95% para cuatro modelos genéticos. Resultados: Se incluyeron cuatro estudios, constituyendo 875 participantes para el rs12979860 y 718 para rs8099917. No se observó desviación del equilibrio Hardy-Weinberg (p>0,05). No se evidenció asociación estadísticamente significativa de rs12979860 con riesgo de infección por HTLV-1 (modelo alélico: OR= 0,98; p= 0,89; modelo recesivo: OR= 1,03; p=0,85; modelo dominante: OR= 0,91; p= 0,63; modelo sobredominante OR= 0,92; p= 0,59); ni del rs8099917 (modelo alélico: OR= 1,01; p=0,97; modelo recesivo: OR= 0,95; p=0,78; modelo dominante: OR= 1,09; p=0,80; modelo sobredominante: OR= 1,12; p=0,53). Conclusión: El metaanálisis muestra que los SNPs rs8099917 y rs12979860, no están asociados con el riesgo de infección por HTLV-1. Se resaltan la necesidad de más investigaciones de tipo caso-control que permitan contrastar nuestra conclusión.
The investigation of genetic risk factors is important for understanding susceptibility to Human T-Cell Lymphotropic Virus Type 1 (HTLV-1). Although IL28B gene polymorphisms have been implicated in infection risk for other viruses, their role in HTLV-1 infection risk remains uncertain. Objective: to determine whether the Single Nucleotide Polymorphisms (SNPs) rs8099917 and rs12979860 in the IL28B gene are associated with the risk of HTLV-1 infection. Material and Methods: a meta-analysis of case-control studies was performed. A search was conducted in PubMed, Google Scholar, and Scopus. Genotypic frequencies of the polymorphisms were extracted. Using a genetic association meta-analysis with the Metagenyo software, Odds Ratios (OR) and 95% confidence intervals were estimated for four genetic models. Results: four studies were included, comprising 875 participants for rs12979860 and 718 for rs8099917. No deviation from Hardy-Weinberg equilibrium was observed (p>0.05). No statistically significant association was found between rs12979860 and HTLV-1 infection risk (allelic model: OR= 0.98; p= 0.89; recessive model: OR= 1.03; p=0.85; dominant model: OR= 0.91; p= 0.63; overdominant model: OR= 0.92; p= 0.59), nor for rs8099917 (allelic model: OR= 1.01; p=0.97; recessive model: OR= 0.95; p=0.78; dominant model: OR= 1.09; p=0.80; overdominant model: OR= 1.12; p=0.53). Conclusion: This meta-analysis indicates that the SNPs rs8099917 and rs12979860 are not associated with the risk of HTLV-1 infection. This underscores the need for further case-control studies to validate our findings.
The investigation of genetic risk factors is important for understanding susceptibility to Human T-Cell Lymphotropic Virus Type 1 (HTLV-1). Although IL28B gene polymorphisms have been implicated in infection risk for other viruses, their role in HTLV-1 infection risk remains uncertain. Objective: to determine whether the Single Nucleotide Polymorphisms (SNPs) rs8099917 and rs12979860 in the IL28B gene are associated with the risk of HTLV-1 infection. Material and Methods: a meta-analysis of case-control studies was performed. A search was conducted in PubMed, Google Scholar, and Scopus. Genotypic frequencies of the polymorphisms were extracted. Using a genetic association meta-analysis with the Metagenyo software, Odds Ratios (OR) and 95% confidence intervals were estimated for four genetic models. Results: four studies were included, comprising 875 participants for rs12979860 and 718 for rs8099917. No deviation from Hardy-Weinberg equilibrium was observed (p>0.05). No statistically significant association was found between rs12979860 and HTLV-1 infection risk (allelic model: OR= 0.98; p= 0.89; recessive model: OR= 1.03; p=0.85; dominant model: OR= 0.91; p= 0.63; overdominant model: OR= 0.92; p= 0.59), nor for rs8099917 (allelic model: OR= 1.01; p=0.97; recessive model: OR= 0.95; p=0.78; dominant model: OR= 1.09; p=0.80; overdominant model: OR= 1.12; p=0.53). Conclusion: This meta-analysis indicates that the SNPs rs8099917 and rs12979860 are not associated with the risk of HTLV-1 infection. This underscores the need for further case-control studies to validate our findings.
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Vol. 48, No. 2