Reversibility and Time-Dependency of Contrast Medium Induced Inhibition of 3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyl-tetrazolium bromide (MTT) Conversion in Renal Proximal Tubular Cells In Vitro

Abstract

Contrast medium induced cytotoxicity consisted of a reversible part and an irreversible part. There was no difference in cytotoxicity between iomeprol and iodixanol over a broad range of concentrations and incubation-times.