Estudio comparativo de las fases de la hemostasia en dos líneas de ratas de laboratorio

Abstract

The objective of the research was to compare the hemostasis phases in laboratory rats of the BIOU lines: \nWistar and BIOU: Sprague-Dawley. Methodology: 10 rats from each of the lines were used, produced by the \nBioterio of the University of Los Andes, with body weight between 370 and 400 g, it was determined: bleeding \ntime, platelet count, prothrombin time (PT), partial time of activated thromboplastin (aPTT), clotting time and \nfibrinogen. Results: bleeding time and PT were significantly lower in BIOU: Sprague-Dawley rats (p = 0.002 \nand p = 0.011 respectively). There was no significant difference in platelet count, aPTT, clotting time and \nfibrinogen between both lines of rats (p> 0.05). Conclusion: differences were observed between the BIOU: \nSprague-Dawley and BIOU: Wistar laboratory rats, both in the primary hemostasis as in secondary hemostasis; \nspecifically, bleeding time and PT were significantly lower in BIOU: Sprague-Dawley rats. The differences \nfound could be explained by variations in the genetic bases of each line of rats, which influence platelet \nfunction or the expression and / or activity of coagulation factors, anticoagulant proteins and components of \nthe fibrinolytic system.